Why the study?
Is plasma renin activity a valid estimation of plasma angiotensin status?
Population
2752 individual plasma samples
Comparison
Measurement of plasma renin activity vs Initial angiotensin I concentration
Design
Other
Authors
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Supports PRA as angiotensin proxy below threshold in vitro; leaves open in vivo validation and clinical adoption.
Is plasma renin activity a valid estimation of plasma angiotensin status?
The study validates the use of plasma renin activity measurement as a reliable reflection of circulating angiotensin II levels, provided activity is below 60 ng ml-1 h-1.
Roulston et al. (1978) studied this question.
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