Why the study?
Does a first-line perindopril/indapamide combination reduce left ventricular mass more than atenolol in patients with essential hypertension?
Population
214 patients with essential hypertension (124 with left ventricular hypertrophy at baseline)
Comparison
Perindopril 2 mg / indapamide 0.625 mg… vs Atenolol 50 mg
Design
RCT, randomized, double-blind
Follow-up
12 months
Authors
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Supports perindopril/indapamide over atenolol for LV mass regression in hypertension; extends evidence favoring ACEI/diuretic regimens.
Does a first-line perindopril/indapamide combination reduce left ventricular mass more than atenolol in patients with essential hypertension?
First-line combination therapy with perindopril/indapamide is more effective than atenolol in reducing left ventricular mass and hypertrophy in patients with essential hypertension.
Mallion et al. (2004) studied this question.
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