Why the study?
Does long-term therapy with ACE inhibitors, ARBs, or beta-blockers reduce the risk of incident atrial fibrillation in hypertensive patients compared to calcium-channel blockers?
Population
4,661 patients with incident atrial fibrillation and 18,642 matched control participants from a population…
Comparison
Current exclusive long-term therapy with… vs Current exclusive long-term therapy with…
Design
Case-control
Authors
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May support preferring ACEIs/ARBs/beta-blockers over CCBs for AF prevention in hypertension; leaves open need for RCTs to confirm causality.
Does long-term therapy with ACE inhibitors, ARBs, or beta-blockers reduce the risk of incident atrial fibrillation in hypertensive patients compared to calcium-channel blockers?
In hypertensive patients, long-term use of ACE inhibitors, ARBs, or beta-blockers is associated with a significantly lower risk of incident atrial fibrillation compared to calcium-channel blockers.
Beat Schaer (2010) studied this question.
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