Key result
Single-drug use of ACE inhibitors or ARBs, compared with diuretics, was associated with lower risk of incident atrial fibrillation in hypertensive patients (OR 0.63; 95% CI 0.44-0.91).
Why the study?
Does antihypertensive treatment with ACE inhibitors/ARBs or beta-blockers reduce the risk of incident atrial fibrillation in hypertensive patients without heart failure compared to diuretics?
Population
2,322 patients pharmacologically treated for hypertension without heart failure, from an integrated…
Comparison
Single-drug antihypertensive treatment with ACE… vs Single-drug antihypertensive treatment with a…
Design
Case-control
Authors
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Should not yet change antihypertensive choices; leaves open whether ACEI/ARB reduce incident AF versus diuretics in hypertension.
Case-Control (n=2,322)
Does antihypertensive treatment with ACE inhibitors/ARBs or beta-blockers reduce the risk of incident atrial fibrillation in hypertensive patients without heart failure compared to diuretics?
Odds Ratio: 0.63 (95% CI 0.44–0.91)
In hypertensive patients without heart failure, single-drug therapy with ACE inhibitors or ARBs is associated with a significantly reduced risk of incident atrial fibrillation compared to diuretics.
Heckbert et al. (2009) conducted a case-control in Hypertension (n=2,322). ACE inhibitors or ARBs vs. Diuretics was evaluated on Incident atrial fibrillation (OR 0.63, 95% CI 0.44-0.91). Single-drug use of ACE inhibitors or ARBs, compared with diuretics, was associated with lower risk of incident atrial fibrillation in hypertensive patients (OR 0.63; 95% CI 0.44-0.91).
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