Early Detection of Vascular Dysfunction in Type I Diabetes

59 young adult subjects, including 38 with type I (insulin-dependent) diabetes without overt evidence of angiopathy (15 with glycosylated hemoglobin [GHb] ≤9.5%, 23 with GHb ≥12.5%) and 21 control subjects.

5 minutes of arterial occlusion in the forearm (ischemia)

Healthy control subjects and comparison between diabetic patients with good (GHb ≤9.5%) versus poor (GHb ≥12.5%) glycemic control

Forearm blood flow and transcutaneous oxygen tension response to ischemia measured by venous occlusion plethysmography and transcutaneous oxygen electrodesurrogate