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July 7, 2009European Journal of Heart FailureOpen Access

Increased Late Sodium Currents are Related to Transcription of Neuronal Isoforms in a Pressure-Overload Model

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Population

Pressure-overload rat models created by 16-week constriction of the ascending aorta (HF)

Comparison

16-week constriction of the ascending aorta vs Sham operation

Design

Preclinical

Follow-up

16 weeks

Authors

YXYutao XiValve (United States)GWGeru WuFirst Affiliated Hospital of Xi'an Jiaotong UniversityLYLin Wei YangPeking University

Discussion

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Overview

May link neuronal Na channel isoforms to increased I(NaL) in HF; hypothesis-generating for targeted inhibition in patients.

Structured PICO

P
Population
Pressure-overload rat models created by 16-week constriction of the ascending aorta (HF)
I
Intervention
16-week constriction of the ascending aorta (pressure-overload model)
C
Comparator
Sham operation
O
Outcome
Late sodium current (I(NaL)) and expression of sodium channel (NaCh) isoformssurrogate

Up-regulation of neuronal sodium channel isoforms SCN1a and SCN8a in a rat model of pressure-overload heart failure may contribute to increased late sodium currents and action potential prolongation.

Cite This Study

Xi et al. (2009) studied this question.

synapsesocial.com/papers/6a8294521228d2aa8d21df2dhttps://doi.org/10.1093/eurjhf/hfp092

Topics

Heart failureHFrEF treatmentHypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes.1989 · 190 citations
  2. 2Functional Analysis of the Mouse Scn8a Sodium Channel1998 · 254 citations
  3. 3A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties1992 · 393 citations
  4. 4Chronic Heart Failure Slows Late Sodium Current in Human and Canine Ventricular Myocytes: Implications for Repolarization Variability2006 · 189 citations
  5. 5Expression pattern of neuronal and skeletal muscle voltage‐gated Na+ channels in the developing mouse heart2005 · 107 citations