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February 27, 2008Current Medical Research and Opinion

Mean msSBP/DBP reductions of 22.3/14.4 mmHg were observed at 6 months, with 73.4% achieving BP control and a low rate (2.5%) of serum potassium elevations > 5.5 mmol/L.

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Why the study?

Does aliskiren/valsartan combination therapy safely reduce blood pressure in patients with hypertension?

Population

601 patients with hypertension (msDBP ≥ 90 and < 110 mmHg)

Design

Cohort, open-label

Follow-up

6 months (interim analysis)

Authors

SCSteven G. ChrysantAMAlexander V. MurrayUHUta C. Hoppe

Discussion

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Overview

Associated with substantial BP reductions and control in this cohort; extends prior data but leaves open need for RCT confirmation.

Structured PICO

Does aliskiren/valsartan combination therapy safely reduce blood pressure in patients with hypertension?

P
Population
601 patients with hypertension (msDBP ≥ 90 and < 110 mmHg)
I
Intervention
Aliskiren/valsartan 150/160 mg for 2 weeks followed by forced titration to aliskiren/valsartan 300/320 mg once daily for a targeted duration of 52 weeks, with optional hydrochlorothiazide (HCTZ) addition allowed from week 8
O
Outcome
Safety of combination therapy, including predefined safety outcome of potassium elevationssafety

Long-term treatment with aliskiren/valsartan 300/320 mg provided clinically significant BP lowering with a low rate of potassium elevations in hypertensive patients.

Limitations

  • lack of an active comparator group

Cite This Study

Chrysant et al. (2008) studied this question.

synapsesocial.com/papers/6a82aa2c23a6926b671e1287https://doi.org/10.1185/030079908x280581
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term safety and efficacy of aliskiren and valsartan combination with or without the addition of HCT in patients with hypertension2010 · 14 citations
  2. 2Randomized Study of Antihypertensive Efficacy and Safety of Combination Aliskiren/Valsartan vs Valsartan Monotherapy in Hypertensive Participants With Type 2 Diabetes Mellitus2012 · 39 citations
  3. 3Aliskiren, an Orally Effective Renin Inhibitor, Provides Antihypertensive Efficacy Alone and in Combination With Valsartan2006 · 214 citations
  4. 4Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension2009 · 66 citations
  5. 5Hormonal and Hemodynamic Effects of Aliskiren and Valsartan and Their Combination in Sodium-Replete Normotensive Individuals2007 · 61 citations