Key result
Aliskiren/valsartan combination with or without HCT provided a mean BP reduction of 20.5/13.4 mmHg at 54 weeks and 28.8/18.3 mmHg at 80 weeks in patients with hypertension.
Why the study?
Does aliskiren/valsartan combination with or without HCT reduce blood pressure in patients with hypertension?
Does aliskiren/valsartan combination with or without HCT reduce blood pressure in patients with hypertension?
Long-term treatment with aliskiren/valsartan with or without HCT provides clinically meaningful blood pressure reductions and is well-tolerated in patients with hypertension.
Answers are grounded in this paper and cite their sources.
May support aliskiren/valsartan ± HCT for hypertension; hypothesis-generating and leaves open RCT confirmation.
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Chrysant et al. (2010) studied hypertension (n=601). aliskiren/valsartan combination with or without HCT was evaluated on change in msDBP and msSBP from baseline to endpoint (54-week and 80-week) (mean BP reduction of 20.5/13.4 mmHg at 54 weeks). Aliskiren/valsartan combination with or without HCT provided a mean BP reduction of 20.5/13.4 mmHg at 54 weeks and 28.8/18.3 mmHg at 80 weeks in patients with hypertension.
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