Why the study?
Does the renin-angiotensin-aldosterone system activity differ between normal pregnancy and toxaemia of pregnancy?
Population
122 pregnant women (56 in a prospective study, 66 in a second study)
Comparison
Sodium restriction and sodium loading in… vs Normal pregnancy vs toxaemia of pregnancy
Design
Cohort
Follow-up
Up to 40 weeks of pregnancy
Authors
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May mark toxaemia risk via sustained late-pregnancy renin activity; leaves open causal role and need for prospective validation.
Does the renin-angiotensin-aldosterone system activity differ between normal pregnancy and toxaemia of pregnancy?
Heightened activity of the renin-angiotensin-aldosterone system that fails to decline in late pregnancy may be an aggravating factor in established toxaemia.
Gordon et al. (1973) studied this question.
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