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March 1, 1979The Journal of Clinical Endocrinology & Metabolism

Free and Conjugated Plasma and Urinary Dopamine in Human Hypertension*

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Why the study?

Are plasma and urinary dopamine levels altered in patients with essential hypertension, primary aldosteronism, and phaeochromocytoma compared to controls?

Population

52 subjects: 29 patients with essential hypertension, 4 with primary aldosteronism, 3 with…

Comparison

Measurement of plasma and urinary free and… vs Control subjects

Design

Case-control

Authors

OKOtto KuchelMedical Council of CanadaNBNguyen T. BuuHotel Dieu HospitalTUThomas UngerGeneral Cardiology

Discussion

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Implication

May suggest compensatory dopaminergic mechanisms in hypertension; hypothesis-generating and should not yet change practice.

Structured PICO

Are plasma and urinary dopamine levels altered in patients with essential hypertension, primary aldosteronism, and phaeochromocytoma compared to controls?

P
Population
52 subjects: 29 patients with essential hypertension (EH), 4 with primary aldosteronism (PA), 3 with phaeochromocytoma (normotensive phase), and 16 control subjects.
I
Intervention
Measurement of plasma and urinary free and conjugated dopamine, and response to IV furosemide
C
Comparator
Control subjects
O
Outcome
Plasma and urinary free and conjugated dopamine levelssurrogate

Elevated plasma total dopamine in several forms of hypertension suggests a compensatory dopaminergic vasodilator system, while low urinary free dopamine excretion in essential hypertension suggests an intrinsic defect in a dopamine-modulated natriuretic mechanism.

Cite This Study

Kuchel et al. (1979) studied this question.

synapsesocial.com/papers/6a82bb2d2bae860373a0c35ahttps://doi.org/10.1210/jcem-48-3-425

Topics

Hypertension management
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