Why the study?
Does renal dopaminergic activity and the conversion of l-DOPA to dopamine differ between normotensive subjects and patients with low renin essential hypertension?
Population
29 hospitalized subjects on a constant diet, comprising 9 normotensive subjects and 20 patients with…
Comparison
Single oral administration of l-DOPA (400mg). vs Normotensive subjects and baseline conditions.
Design
Cross-sectional
Authors
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Reduced renal DOPA-to-dopamine conversion may impair natriuresis in low-renin hypertension; leaves open causality and need for prospective trials.
Does renal dopaminergic activity and the conversion of l-DOPA to dopamine differ between normotensive subjects and patients with low renin essential hypertension?
Patients with low renin essential hypertension exhibit reduced renal conversion of DOPA to dopamine, which may contribute to their attenuated natriuresis.
Aoki et al. (1989) studied this question.
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