Why the study?
Is renal dopaminergic activity suppressed in young healthy normotensive subjects with a family history of hypertension?
Population
Young healthy normotensive subjects with [FH(+)] and without [FH(-)] a family history of hypertension
Comparison
Dopamine infusion vs Comparison between FH(+) and FH(-) subjects
Design
Cross-sectional
Authors
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May indicate early dopaminergic defect in hypertension-prone subjects; hypothesis-generating and requires prospective validation before clinical relevance.
Is renal dopaminergic activity suppressed in young healthy normotensive subjects with a family history of hypertension?
Renal dopaminergic activity is already suppressed at the prehypertensive stage in individuals with a family history of hypertension, suggesting a primary pathophysiological role.
Iimura et al. (1990) studied this question.