Why the study?
Does vitamin therapy with folic acid, pyridoxine, and cyanocobalamin reduce the progression of carotid atherosclerosis in patients with vascular disease regardless of baseline homocyst(e)ine levels?
Population
101 patients with vascular disease (51 with initial plasma homocystine levels >14 micromol/L, and 50 with…
Comparison
Vitamin therapy with folic acid 2.5 mg… vs Patients' own pre-treatment progression rates
Design
Cohort
Authors
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May support B-vitamin therapy to regress carotid plaque irrespective of homocysteine; hypothesis-generating and requires RCT confirmation.
Does vitamin therapy with folic acid, pyridoxine, and cyanocobalamin reduce the progression of carotid atherosclerosis in patients with vascular disease regardless of baseline homocyst(e)ine levels?
Vitamin therapy with folic acid, pyridoxine, and cyanocobalamin regresses carotid plaque in patients with vascular disease regardless of whether their baseline homocyst(e)ine levels are above or below 14 micromol/L.
Daniel G. Hackam (2000) studied this question.
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