Why the study?
Do AT1 or AT2 receptor antagonists prevent microvascular changes in Angiotensin II-induced cardiac hypertrophy in rats?
Do AT1 or AT2 receptor antagonists prevent microvascular changes in Angiotensin II-induced cardiac hypertrophy in rats?
In a rat model, Angiotensin II-induced cardiac hypertrophy is associated with capillary rarefaction and arteriolar growth, processes that are independently regulated by AT1 and AT2 receptors.
No takes yet. Share an insight, caveat, or question.
Rat data on AT1/AT2 effects should not change practice; leaves open receptor-specific microvascular regulation in human hypertrophy.
Sabri et al. (1998) studied this question.
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