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June 1, 1977Journal of General Virology

An Extended Genetic Recombination Map for Foot-and-Mouth Disease Virus

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Population

Foot-and-Mouth Disease Virus temperature-sensitive mutants

Comparison

Genetic recombination mapping using a new… vs Original recombination map

Design

Preclinical

Authors

DMD. McCahonThe Pirbright InstituteWSW. R. SladeThe Pirbright InstituteRPR. A. J. PristonThe Pirbright Institute

Discussion

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Overview

Extends FMDV recombination mapping in animal models; leaves open implications for viral evolution and vaccine research.

Structured PICO

P
Population
Foot-and-Mouth Disease Virus (FMDV) temperature-sensitive (ts) mutants (35 original mutagen-induced and 33 newly mapped ts mutants)
I
Intervention
Genetic recombination mapping using a new standardization technique
C
Comparator
Original recombination map (Lake, Priston & Slade, 1975)
O
Outcome
Size and detail of the genetic recombination map

The study extends the genetic recombination map of the foot-and-mouth disease virus, revealing a concentration of mutations near the guanidine locus.

Cite This Study

McCahon et al. (1977) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f4https://doi.org/10.1099/0022-1317-35-3-555
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Properties of Temperature-sensitive Mutants of the KENYA 3/57 Strain of Foot-and-mouth Disease Virus1970 · 10 citations
  2. 2Improved Technique for the Isolation of Temperature-Sensitive Mutants of Foot-and-Mouth Disease Virus1973 · 14 citations
  3. 3Recombination Between Conditional Lethal Mutants Within a Strain of Foot-and-mouth Disease Virus1968 · 25 citations
  4. 4A Genetic Recombination Map of Foot-and-Mouth Disease Virus1975 · 34 citations
  5. 5Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination1975 · 22 citations