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June 1, 1975Journal of General Virology

A Genetic Recombination Map of Foot-and-Mouth Disease Virus

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Population

Pacheco strain of type O foot-and-mouth disease virus (60 ts mutants)

Design

Preclinical

Authors

JLJ. R. LakeHealth Promotion BoardRPR. A. J. PristonThe Pirbright InstituteWSW. R. SladeThe Pirbright Institute

Discussion

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Overview

Does not support clinical practice changes; leaves open further virological mapping in animal models.

Structured PICO

P
Population
Pacheco strain of type O foot-and-mouth disease virus (60 ts mutants)
I
Intervention
Treatment with either 5-fluorouracil or hydroxylamine and subsequent genetic recombination mapping (two-factor and three-factor crosses)
O
Outcome
Location of mutations in a linear arrangement (genetic recombination map)

The study successfully mapped 34 mutations of the foot-and-mouth disease virus in a linear arrangement, locating the guanidine resistance mutation near the middle.

Cite This Study

Lake et al. (1975) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f6https://doi.org/10.1099/0022-1317-27-3-355
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recombination Between Conditional Lethal Mutants Within a Strain of Foot-and-mouth Disease Virus1968 · 25 citations
  2. 2Properties of Temperature-sensitive Mutants of the KENYA 3/57 Strain of Foot-and-mouth Disease Virus1970 · 10 citations
  3. 3Improved Technique for the Isolation of Temperature-Sensitive Mutants of Foot-and-Mouth Disease Virus1973 · 14 citations
  4. 4Physiological Studies of Conditional Lethal Mutants of Bacteriophage T4D1963 · 807 citations