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September 1, 1998Journal of VirologyOpen Access

Classical Swine Fever Virus Leader Proteinase N pro Is Not Required for Viral Replication in Cell Culture

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Population

Cell culture infected with classical swine fever virus (CSFV) strain Alfort/187

Comparison

Recombinant virus vA187-Ubi vs Parent vA187-1 virus

Design

Preclinical

Authors

JTJon-Duri TratschinCMChristian MoserNRNicolas Ruggli

Discussion

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Overview

Npro dispensability for CSFV replication in vitro supports attenuation strategies; leaves open in vivo roles and vaccine applications.

Structured PICO

P
Population
Cell culture infected with classical swine fever virus (CSFV) strain Alfort/187
I
Intervention
Recombinant virus vA187-Ubi (sequence encoding viral leader proteinase Npro replaced by murine ubiquitin gene)
C
Comparator
Parent vA187-1 virus
O
Outcome
Viral replication and growth characteristics

The viral leader proteinase Npro of classical swine fever virus is not required for viral replication in cell culture.

Cite This Study

Tratschin et al. (1998) studied this question.

synapsesocial.com/papers/6a82f4bf3b194ef92e581bd1https://doi.org/10.1128/jvi.72.9.7681-7684.1998
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA1996 · 207 citations
  2. 2The foot-and-mouth disease virus leader proteinase gene is not required for viral replication1995 · 136 citations
  3. 3Processing of pestivirus polyprotein: cleavage site between autoprotease and nucleocapsid protein of classical swine fever virus1993 · 165 citations
  4. 4Cytopathogenicity of classical swine fever virus caused by defective interfering particles1995 · 73 citations
  5. 5Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus1995 · 93 citations