February 17, 1992FEBS LettersOpen Access

Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein

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Population

Human umbilical vein endothelial cells (HUVECs) in primary culture

Design

Preclinical

Authors

YFYasushi FujitaniNovartis (Switzerland)KOKyoko OdaUniversity of Shizuoka MTMisato TakimotoFood Research Institute

Discussion

Member takes

Implication

ETB presence on endothelium may support autocrine vasodilation; leaves open in vivo confirmation and any clinical relevance.

Structured PICO

Population

Human umbilical vein endothelial cells (HUVECs) in primary culture

Intervention

Phosphoramidon (inhibitor of ET-converting enzyme) followed by [125I]ET-1 binding

Outcome

Detection and characterization of ET receptorssurrogate

The study identifies the presence of ETB receptors on human umbilical vein endothelial cells, suggesting an autocrine mechanism for endothelin-induced vasodilation.

Cite This Study

Fujitani et al. (1992) studied this question.

synapsesocial.com/papers/6a830c4e7a9386604693c580 https://doi.org/10.1016/0014-5793(92)80026-d

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Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider