The study demonstrates that measuring anaerobic glycolysis in relation to poliomyelitis requires specific experimental designs to account for coenzymes and phosphate esters.
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Requires cofactor control in ex vivo glycolysis assays; leaves open relevance to in vivo neurological models.
Experiments with mouse brain, homogenates show that the anaerobic glycolysis of such preparations can be increased tenfold by addition of appropriate coenzymes and phosphate esters. The previously reported alterations in anaerobic glycolysis during poliomyelitis, as measured with low activity preparations, are believed to be of doubtful value in so far as the changes may be related to any specific phase of metabolism. In order to obtain this type of information, the experiment usually must be designed specifically to measure the desired factor.
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Utter et al. (1945) studied this question.
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