Population
Rats with chronic two-kidney, one clip Goldblatt hypertension induced by unilateral renal artery clipping…
Comparison
Antihypertensive treatment with phenoxybenzamine… vs Sham-operated normotensive rats and…
Design
Preclinical
Follow-up
17 or 20 weeks
Authors
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Hypothesis-generating for vascular remodeling in chronic renovascular hypertension; leaves open human relevance and should not change practice.
Increased synthesis of vascular non-collagenous protein and collagen in small arteries plays a major role in the pathogenesis of chronic 2K-1C hypertension, while renin does not contribute to blood pressure elevation in the maintenance phase.
Nakada et al. (1982) studied this question.
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