September 1, 1996The Journal of Urology

Increased Vascular Collagen and Noncollagenous Protein Synthesis Contributes to Sustain Chronic Phase of Two-Kidney, One-Clip Renovascular Hypertension

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Why the study?

Does splanchnicotomy, beta-aminopropionitrile, or captopril reduce vascular protein synthesis and blood pressure in acute versus chronic phases of 2K-1C hypertensive rats?

Population

Two-kidney one-clip (2K-1C) hypertensive rats in acute or chronic hypertensive phase

Comparison

Splanchnicotomy, beta-aminopropionitrile, or… vs Untreated 2K-1C rats or comparison between…

Design

Preclinical

Authors

TNTeruhiro NakadaYamagata University YIYoshiaki IijimaTohoku University YKYōko KubotaNational Cancer Center

Discussion

Member takes

Implication

Implicates vascular protein synthesis in sustaining chronic renovascular hypertension independent of RAS; leaves open therapeutic translation from this rat model.

Structured PICO

Does splanchnicotomy, beta-aminopropionitrile, or captopril reduce vascular protein synthesis and blood pressure in acute versus chronic phases of 2K-1C hypertensive rats?

Population

Two-kidney one-clip (2K-1C) hypertensive rats in acute or chronic hypertensive phase

Intervention

Splanchnicotomy, beta-aminopropionitrile (collagen inhibitor), or captopril (angiotensin converting enzyme inhibitor)

Comparator

Untreated 2K-1C rats (implied) or comparison between treatments and phases

Outcome

Incorporation rates of 3H-proline into vascular collagen, noncollagenous protein and elastin, plasma level of the R-A system, and blood pressuresurrogate

Increased noncollagenous protein and collagen synthesis in small arteries contributes to the chronic phase of 2K-1C renovascular hypertension, independent of the renin-angiotensin system.

Cite This Study

Nakada et al. (1996) studied this question.

synapsesocial.com/papers/6a892a4a789d3eba981a3624 https://doi.org/10.1016/s0022-5347(01)65746-x

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Implication

Implicates vascular protein synthesis in sustaining chronic renovascular hypertension independent of RAS; leaves open therapeutic translation from this rat model.

Increased Vascular Collagen and Noncollagenous Protein Synthesis Contributes to Sustain Chronic Phase of Two-Kidney, One-Clip Renovascular Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased Vascular Collagen and Noncollagenous Protein Synthesis Contributes to Sustain Chronic Phase of Two-Kidney, One-Clip Renovascular Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider