June 1, 1996Shock

The Lymphatic Circulation Plays a Dynamic Role in Blood Volume and Plasma Protein Restitution After Hemorrhage

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Population

Splenectomized sheep prepared with thoracic duct and vascular catheters (n=11)

Comparison

Hemorrhage (bled 25% of blood volume over 5 min) vs Observation (SHAM)

Design

Preclinical

Follow-up

48 hours

Authors

Discussion

Lymphatic restitution of plasma proteins may aid volume recovery after hemorrhage; leaves open translation to clinical shock management.

Population

Splenectomized sheep prepared with thoracic duct and vascular catheters (n=11)

Intervention

Hemorrhage (bled 25% of blood volume over 5 min)

Comparator

Observation (SHAM)

Outcome

Thoracic duct lymph flow, thoracic duct lymph protein, plasma protein, mean arterial pressure, and blood volume restitutionsurrogate

The lymphatic circulation plays a significant, dynamic role in restoring blood volume and plasma protein mass after hemorrhage.

Lloyd et al. (1996) studied this question.

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