March 25, 1996FEBS LettersOpen Access

The role of ETB receptors in normotensive and hypertensive rats as revealed by the non‐peptide selective ETB receptor antagonist Ro 46‐8443

View Full Paper

Ask AI

Bookmark

Why the study?

Does Ro 46-8443 affect blood pressure differently in normotensive versus hypertensive rat models?

Population

Normotensive rats, spontaneously hypertensive rats, DOCA rats, and rats rendered hypertensive by chronic…

Design

Preclinical

Authors

MCMartine ClozelActelion (Switzerland)VBVolker BreuActelion (Switzerland)

Discussion

Member takes

Implication

Differential ETB blockade effects across hypertension models warrant caution extrapolating to humans; extends context-dependent ETB signaling insights in preclinical research.

Structured PICO

Does Ro 46-8443 affect blood pressure differently in normotensive versus hypertensive rat models?

Population

Normotensive rats, spontaneously hypertensive rats (SHR), DOCA rats, and rats rendered hypertensive by chronic L-NAME

Intervention

Ro 46-8443 (non-peptidic selective ETB receptor antagonist)

Outcome

Blood pressuresurrogate

ETB receptors predominantly mediate a vasoconstrictor tone in normotensive rats, but mediate endothelial vasorelaxation in SHR and DOCA hypertensive rats.

Cite This Study

Clozel et al. (1996) studied this question.

synapsesocial.com/papers/6a8386e145d6ebe77211ab06 https://doi.org/10.1016/0014-5793(96)00212-8

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Differential ETB blockade effects across hypertension models warrant caution extrapolating to humans; extends context-dependent ETB signaling insights in preclinical research.

The role of ETB receptors in normotensive and hypertensive rats as revealed by the non‐peptide selective ETB receptor antagonist Ro 46‐8443

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

The role of ETB receptors in normotensive and hypertensive rats as revealed by the non‐peptide selective ETB receptor antagonist Ro 46‐8443

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider