Population
Isolated 2 mm segments of the tail artery from spontaneously hypertensive and normotensive Wistar-Kyoto rats
Comparison
Endothelin-1 (10-10 M) and vasopressin (10-10 M)… vs Arteries from normotensive WKY rats compared to…
Design
Preclinical
Authors
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Impaired potentiation in hypertensive rat arteries suggests altered vascular reactivity; hypothesis-generating for human hypertension and requires clinical validation.
Potentiation of sympathetic vasoconstriction by endothelin-1 and vasopressin is impaired in hypertensive rats and is mediated mainly by ETA and V1 receptors.
Angel Luis García-Villalón (2000) studied this question.
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