Why the study?
Does voluntary running exercise reduce blood pressure and suppress the renin-angiotensin system in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) at 5 weeks of age
Comparison
Voluntary running exercise vs Sedentary control group
Design
Preclinical
Authors
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Animal data link exercise to RAS effects in SHR; leaves open translation to human hypertension management.
Does voluntary running exercise reduce blood pressure and suppress the renin-angiotensin system in spontaneously hypertensive rats?
Voluntary running exercise lowers systolic blood pressure in both hypertensive and normotensive rats, and this effect is associated with suppression of the renin-angiotensin system in hypertensive rats.
Hayashi et al. (2000) studied this question.