Why the study?
Does hydralazine prevent changes in the contractile response of aortic and portal vein strips in hypertensive rats?
Population
Rats with spontaneous hypertension (SHR) (13-week-old) or DOCA/salt-induced hypertension
Comparison
Hydralazine added to drinking solution for 3 weeks vs Control rats
Design
Preclinical
Follow-up
3 weeks
Authors
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Suggests pressure-dependent aortic but not portal vein changes in rat hypertension models; hypothesis-generating for independent venous mechanisms.
Does hydralazine prevent changes in the contractile response of aortic and portal vein strips in hypertensive rats?
In hypertensive rats, hydralazine prevents high blood pressure-induced reductions in aortic contractile response, but does not affect portal vein contractile changes, suggesting the latter is independent of blood pressure.
Pang et al. (2008) studied this question.
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