The characteristic spindle abnormality in myotonic dystrophy appears to be driven by fragmentation of the poles of intrafusal muscle fibres, likely due to mechanical stresses from myotonia.
No takes yet. Share an insight, caveat, or question.
May link myotonia to targeted intrafusal damage; leaves open validation in larger myotonic dystrophy cohorts.
Swash et al. (1975) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: