The study suggests that intrafusal muscle fibre splitting in myotonic dystrophy triggers a regenerative response.
Answers are grounded in this paper and cite their sources.
Caution against altering myotonic dystrophy management based on biopsy findings; leaves open regenerative mechanisms as therapeutic targets.
Studies of the extent and complexity of intrafusal muscle fibre splitting in myotonic dystrophy have been carried out in three spindles obtained at muscle biopsy, and in nine spindles found in the lumbrical muscle of a case that came to necropsy. It is suggested that splitting, due to mechanical stresses, leads to a regenerative response in the separated fragments.
No takes yet. Share an insight, caveat, or question.
Swash et al. (1975) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: