What question did this study set out to answer?

To examine whether salt-dependent hypertension and renal structural damage correlate with the extent of chronic nitric oxide inhibition.

May 1, 1996Hypertension

Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade

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Why the study?

Does salt intake and inhibitor dose affect arterial hypertension and renal injury in a rat model of chronic nitric oxide blockade?

Population

Adult male Munich-Wistar rats

Comparison

Oral N omega -nitro-L-arginine methyl ester… vs Untreated controls

Design

Preclinical

Follow-up

Up to 6 weeks

Authors

SYSérgio YamadaUniversidade Estadual de Maringá ASAna Lúcia SassakiHospital Universitário da Universidade de São Paulo CFClarice Kazue FujiharaUniversidade de São Paulo

Discussion

Member takes

Implication

Salt restriction may limit renal injury in nitric oxide blockade models; leaves open dose-dependent mechanisms for translational research.

Key Points

To examine whether salt-dependent hypertension and renal structural damage correlate with the extent of chronic nitric oxide inhibition.
Adult male Munich-Wistar rats were fed low-salt, standard-salt, or high-salt diets and administered oral L-NAME at low (3 mg/kg/day) or high (25 mg/kg/day) doses.
Renal hemodynamics and pressure-natriuresis were assessed at 10 to 15 days, and renal structural changes and albuminuria were evaluated after 6 weeks of follow-up.
Low-dose L-NAME decreased the slope of pressure-natriuresis, producing hypertension exclusively when combined with high salt, whereas high-dose L-NAME caused severe vasoconstriction and right-shifted pressure-natriuresis regardless of salt restriction.
At 6 weeks, high-dose L-NAME produced progressive hypertension, albuminuria, glomerulosclerosis, and interstitial expansion; these lesions were markedly aggravated by sodium overload and largely prevented by sodium restriction.

Structured PICO

Does salt intake and inhibitor dose affect arterial hypertension and renal injury in a rat model of chronic nitric oxide blockade?

Population

Adult male Munich-Wistar rats

Intervention

Oral N omega -nitro-L-arginine methyl ester (L-NAME) treatment at either 3 or 25 mg/kg per day combined with a low salt, standard salt, or high salt diet

Comparator

Untreated controls

Outcome

Arterial hypertension and renal injury (albuminuria, focal glomerular collapse, glomerulosclerosis, and renal interstitial expansion)surrogate

In a rat model of chronic nitric oxide blockade, hypertension and renal injury are exacerbated by high salt intake and high-dose L-NAME, while salt restriction largely prevents renal abnormalities.

Cite This Study

Yamada et al. (1996) studied this question.

synapsesocial.com/papers/6a83fa33f72f0ca72062d397 https://doi.org/10.1161/01.hyp.27.5.1165

Topics

Hypertension management

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Implication

Salt restriction may limit renal injury in nitric oxide blockade models; leaves open dose-dependent mechanisms for translational research.

Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider