Why the study?
Does sodium excess aggravate hypertension and renal injury in rats with chronic NO inhibition?
Population
Rats with chronic NO inhibition induced by N omega-nitro-L-arginine methyl ester (L-NAME)
Comparison
Superimposed salt overload vs Chronic NO inhibition without salt overload
Design
Preclinical
Follow-up
15 and 30 days
Authors
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Salt overload may exacerbate renal injury in NO-inhibited models; leaves open clinical translation and ARB timing in salt-sensitive CKD.
Does sodium excess aggravate hypertension and renal injury in rats with chronic NO inhibition?
Sodium overload aggravates the renal and systemic consequences of chronic NO inhibition, potentially via paradoxical activation of renin secretion, which can be attenuated by angiotensin II inhibition.
Fujihara et al. (1994) studied this question.
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