September 23, 2008Blood Vessels
Evidence for Endothelium-Dependent Vasodilation of Resistance Vessels by Acetylcholine
Why the study?
Does acetylcholine induce vasodilation via endothelium-derived relaxing factor in resistance vessels?
Population
Perfused mesenteric arterial vasculature of rabbits and rats
Comparison
Acetylcholine after 15-min perfusion with 0.2%… vs Vasodilation by ACh without collagenase or…
Design
Preclinical
Authors
Discussion
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Implication
Hypothesis-generating for EDRF in resistance vessel function; leaves open human translation and clinical relevance.
Structured PICO
Does acetylcholine induce vasodilation via endothelium-derived relaxing factor in resistance vessels?
P
Population
Perfused mesenteric arterial vasculature of rabbits and rats
I
Intervention
Acetylcholine (ACh) after 15-min perfusion with 0.2% collagenase (rabbit) or in the presence of hemoglobin (10 microM) (rat)
C
Comparator
Vasodilation by ACh without collagenase or hemoglobin (implied baseline response)
O
Outcome
Vasodilationsurrogate
This preclinical study demonstrates that acetylcholine-induced vasodilation in resistance vessels is primarily mediated by endothelium-derived relaxing factor (EDRF).
Cite This Study
Furchgott et al. (2008) studied this question.