Key result
Intravenous L-arginine significantly decreased peak plasma ammonia (60.6 vs 73.1 µmol/L; p<0.01) and lactate (7.1 vs 8.2 mmol/L; p<0.01) during maximal exercise compared to placebo.
Why the study?
Does intravenous L-arginine supplementation reduce exercise-induced increases in plasma lactate and ammonia in healthy subjects?
Population
8 healthy subjects
Comparison
Intravenous L-arginine hydrochloride salt load vs Intravenous placebo load
Design
RCT, double-blind
Authors
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Reduces metabolic stress during maximal exercise in healthy subjects; confirms acute benefits of intravenous L-arginine in this RCT.
RCT (n=8)
Double-blind
Does intravenous L-arginine supplementation reduce exercise-induced increases in plasma lactate and ammonia in healthy subjects?
Absolute Event Rate: 60.6% vs 73.1%
p-value: p=<0.01
Intravenous L-arginine supplementation reduces exercise-induced increases in plasma lactate and ammonia, potentially by enhancing the nitric oxide pathway.
Schaefer et al. (2002) conducted an RCT in Healthy (n=8). Intravenous L-arginine hydrochloride salt vs. Placebo was evaluated on Peak plasma ammonia (p=<0.01). Intravenous L-arginine significantly decreased peak plasma ammonia (60.6 vs 73.1 µmol/L; p<0.01) and lactate (7.1 vs 8.2 mmol/L; p<0.01) during maximal exercise compared to placebo.
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