Key result
Elevated postoperative serum procalcitonin (>1 ng/ml) was associated with a 30-day mortality rate of 14.28% compared to 3.22% in patients with lower levels, though the difference was not statistically significant (p=0.348).
Why the study?
Few studies have examined the potential role of procalcitonin in anticipating postoperative complications after hepatic surgery.
Does elevated postoperative procalcitonin predict 30-day mortality and complications in patients undergoing hepatectomy for hepatocellular carcinoma?
Cohort (n=52)
No
Does elevated postoperative procalcitonin predict 30-day mortality and complications in patients undergoing hepatectomy for hepatocellular carcinoma?
Absolute Event Rate: 14.28% vs 3.22%
p-value: p=0.348
Elevated serum procalcitonin (>1 ng/ml) 12 hours post-hepatectomy may serve as a prognostic marker for short-term mortality and complications in patients with hepatocellular carcinoma.
Postoperative procalcitonin may aid early complication detection after HCC hepatectomy; leaves open confirmation in larger prospective cohorts.
Background and aims: Few studies have indicated that procalcitonin has a potential role in anticipating postoperative complications of hepatic surgery. Here, we focused on validating the relationship between posthepatectomy and serum procalcitonin as short-term prognostic factors. Methods: Data from 52 patients who underwent hepatectomy (partial) due to hepatocellular carcinoma from June 2018 to July 2023 were enrolled to evaluate the risk factors related to post-hepatectomy complications, especially post-hepatectomy liver failure and 30-day survival. Results: 52 patients were included in the study, and their data was analyzed for PCT. 21 showed raised PCT (>1 ng/ml). Results showed a significant association of PCT with post-hepatectomy liver failure, and the same is associated with 30-day mortality in ICU-admitted patients. Conclusion: Elevated PCT levels in patients after hepatic surgery are associated with poor prognosis and could be used as a potential predictive factor.
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Song et al. (2025) conducted a cohort in Hepatocellular carcinoma (n=52). Elevated serum procalcitonin (>1 ng/ml) vs. Serum procalcitonin <1 ng/ml was evaluated on 30-day mortality (p=0.348). Elevated postoperative serum procalcitonin (>1 ng/ml) was associated with a 30-day mortality rate of 14.28% compared to 3.22% in patients with lower levels, though the difference was not statistically significant (p=0.348).
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