Population
Rabbit left atrial strips and aortic rings
Comparison
Muscarinic agonists in the presence of blocking… vs Muscarinic agonists in the absence of blocking…
Design
Preclinical
Authors
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Animal data suggest cGMP mediates aortic relaxation but not atrial inotropy; leaves open mechanisms and precludes clinical extrapolation.
An increase in cyclic GMP may mediate endothelium-dependent relaxation in rabbit aorta by muscarinic agonists, but does not appear responsible for their direct negative inotropic effects in the rabbit atrium.
Jack Diamond (1987) studied this question.
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