Why the study?
Do 5-HT2 receptor antagonists reduce myocardial damage in isolated ischemic rat hearts?
Population
Isolated rat heart subjected to 25-min global ischemia and 30-min reperfusion
Design
Preclinical
Follow-up
30-min reperfusion
Authors
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Supports 5-HT2 antagonism for ischemic cardioprotection in rats; leaves open clinical translation to human myocardial infarction.
Do 5-HT2 receptor antagonists reduce myocardial damage in isolated ischemic rat hearts?
5-HT2 receptor antagonists provide cardioprotection against ischemic injury in isolated rat hearts, suggesting serotonin exacerbates myocardial damage via 5-HT2 receptors.
Grover et al. (1993) studied this question.
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