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September 23, 2008Blood Vessels

Pre- and Postsynaptic Effects of Angiotensins in the Femoral Artery of Spontaneously Hypertensive and Wistar-Kyoto Rats

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Key result

Angiotensin I and II elicited significantly greater direct contractile responses in femoral arteries from spontaneously hypertensive rats compared to normotensive rats.

Population

Ring segments of femoral arteries from spontaneously hypertensive rats and normotensive Wistar-Kyoto rats

Comparison

Angiotensin I and angiotensin II exposure vs Comparison between SHR and WKY arteries, as well…

Design

Preclinical

Authors

MUMasanobu UrabeCSChe SuTLTony J.-F. Lee

Discussion

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Overview

Suggests vascular angiotensin hypersensitivity in hypertension models; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
Ring segments of femoral arteries from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
I
Intervention
Angiotensin I (AI) and angiotensin II (AII) exposure
C
Comparator
Comparison between SHR and WKY arteries, as well as effects of captopril and endothelium destruction
O
Outcome
Direct contractile response and potentiation of contractile response to transmural adrenergic nerve stimulation (TNS)surrogate

Angiotensin II acts postsynaptically to cause contraction (which is greater in SHR) and presynaptically to promote adrenergic neurotransmission (which is diminished in SHR) in isolated rat femoral arteries.

Cite This Study

Urabe et al. (2008) studied Hypertension. Angiotensin I and Angiotensin II vs. Normotensive Wistar-Kyoto rats was evaluated on Contractile response and potentiation of transmural adrenergic nerve stimulation. Angiotensin I and II elicited significantly greater direct contractile responses in femoral arteries from spontaneously hypertensive rats compared to normotensive rats.

synapsesocial.com/papers/6a845913e7eedc1abc68bb16https://doi.org/10.1159/000158666
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin II (3–8)1996 · 16 citations
  2. 2Role of endothelial cells in responses of spontaneously hypertensive rat mesenteric arteries to norepinephrine and angiotensins.1987
  3. 3Alterations of cyclo‐oxygenase products and NO in responses to angiotensin II of resistance arteries from the spontaneously hypertensive rat1996 · 24 citations
  4. 4Vasodilation Mediated by Angiotensin II Type 2 Receptor Is Impaired in Afferent Arterioles of Young Spontaneously Hypertensive Rats1998 · 54 citations
  5. 5AUGMENTATION OF ANGIOTENSIN II RELEASE FROM ISOLATED MESENTERIC ARTERIES OF WISTAR‐KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS FOLLOWING NEPHRECTOMY1994 · 3 citations