July 1, 1998Journal of General Virology

Binding of a cellular factor to the 3' untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication.

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Population

RNA genomes of entero- and rhinoviruses (polio-, coxsackie- and rhinoviruses)

Comparison

Mutations within the 3' untranslated region (UTR) vs Wild-type virus and revertants

Design

Preclinical

Authors

KMKenneth H. MellitsUniversity of Nottingham JRJonathan B. RohllUniversity College of Osteopathy JAJeffrey W. AlmondUniversity of Oxford

Discussion

Member takes

Implication

Identifies 3' UTR-cellular factor binding as essential for picornavirus replication in animals; leaves open therapeutic targeting pending human validation.

Structured PICO

Population

RNA genomes of entero- and rhinoviruses (polio-, coxsackie- and rhinoviruses)

Intervention

Mutations within the 3' untranslated region (UTR)

Comparator

Wild-type virus and revertants

Outcome

RNA replication and virus viabilitysurrogate

Binding of a cellular factor to the 3' UTR of picornaviruses plays a crucial role in virus replication, which is dependent on RNA secondary structure.

Cite This Study

Mellits et al. (1998) studied this question.

synapsesocial.com/papers/6a845eb0c0e58a00207bf8a3 https://doi.org/10.1099/0022-1317-79-7-1715

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Implication

Identifies 3' UTR-cellular factor binding as essential for picornavirus replication in animals; leaves open therapeutic targeting pending human validation.

Binding of a cellular factor to the 3' untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Binding of a cellular factor to the 3' untranslated region of the RNA genomes of entero- and rhinoviruses plays a role in virus replication.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider