Key result
Constipation-predominant irritable bowel syndrome was associated with increased sympathetic activation, evidenced by a higher resting LF/HF ratio (2.2 vs 1.3, p<0.05) and elevated plasma catecholamines compared to healthy controls.
Population
30 patients with constipation-predominant irritable bowel syndrome and 30 healthy volunteers.
Design
Case-control
Authors
Loading...
May support autonomic assessment in IBS-C; hypothesis-generating and should not yet change practice.
Case-Control (n=60)
No
Absolute Event Rate: 2.2% vs 1.3%
p-value: p=<0.05
Constipation-predominant IBS is associated with sympathetic overbalance, hyperinsulinemia, and reduced ghrelin and cholecystokinin, which may drive the observed gastric myoelectrical activity disturbances.
Mazur et al. (2012) conducted a case-control in Constipation-predominant irritable bowel syndrome (n=60). Constipation-predominant irritable bowel syndrome vs. Healthy volunteers was evaluated on Resting LF/HF-RRI ratio (marker of sympathovagal balance) (p=<0.05). Constipation-predominant irritable bowel syndrome was associated with increased sympathetic activation, evidenced by a higher resting LF/HF ratio (2.2 vs 1.3, p<0.05) and elevated plasma catecholamines compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: