March 5, 2002Circulation

Evidence for Synergy Between α 2 -Adrenergic and Nonadrenergic Mechanisms in Central Blood Pressure Regulation

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Population

Anesthetized rabbits, wild-type (WT) mice, and D79N mice (lacking functional alpha2A-adrenergic receptors)

Comparison

LNP 509, rilmenidine, and alpha-methylnoradrenali… vs Wild-type vs D79N mice; LNP 509 alone vs LNP 509…

Design

Preclinical

Authors

VBVéronique BrubanCentre National de la Recherche Scientifique VEVanessa EstatoFundação Oswaldo Cruz SSStéphan SchannDomain Therapeutics (France)

Discussion

Member takes

Implication

Supports independent and synergistic central BP lowering via imidazoline mechanisms in animals; hypothesis-generating for novel antihypertensives, requires clinical translation.

Structured PICO

Population

Anesthetized rabbits, wild-type (WT) mice, and D79N mice (lacking functional alpha2A-adrenergic receptors)

Intervention

LNP 509 (administered into the cisterna magna or fourth ventricle), rilmenidine, and alpha-methylnoradrenaline (alpha-MNA)

Comparator

Wild-type vs D79N mice; LNP 509 alone vs LNP 509 combined with alpha-MNA or S23757

Outcome

Change in mean arterial pressuresurrogate

Central imidazoline-sensitive, non-alpha2-adrenergic mechanisms can independently lower blood pressure and act synergistically with alpha2-adrenergic mechanisms.

Cite This Study

Bruban et al. (2002) studied this question.

synapsesocial.com/papers/6a85448fc12175303ef23ce4 https://doi.org/10.1161/hc0802.104328

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Implication

Supports independent and synergistic central BP lowering via imidazoline mechanisms in animals; hypothesis-generating for novel antihypertensives, requires clinical translation.