Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1984American Journal of Psychiatry

Calcium channel blockade: possible explanation for thioridazine's peripheral side effects

View Full Paper
Ask AI
Bookmark
Share

Population

Binding sites associated with voltage-operated calcium channels and rat vas deferens

Comparison

Thioridazine vs Verapamil (for binding comparison)

Design

Preclinical

Authors

RGR J GouldKMKathryn M. MurphyIRIan J. Reynolds

Discussion

Loading...

Member takes

Overview

May explain thioridazine side effects via calcium blockade; leaves open human confirmation.

Structured PICO

P
Population
Binding sites associated with voltage-operated calcium channels and rat vas deferens
I
Intervention
Thioridazine
C
Comparator
Verapamil (for binding comparison)
O
Outcome
Binding to 3H-nitrendipine sites and antagonism of potassium-induced, calcium-dependent contractionssurrogate

Thioridazine exhibits calcium channel antagonist effects at therapeutic concentrations, which may explain its cardiac and peripheral side effects.

Cite This Study

Gould et al. (1984) studied this question.

synapsesocial.com/papers/6a854d7efc70cb81dc201aadhttps://doi.org/10.1176/ajp.141.3.352
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Binding of a Calcium Antagonist, [3H]Nitrendipine, to High Affinity Sites in Bovine Aortic Smooth Muscle and Canine Cardiac Membranes1982 · 71 citations
  2. 2Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle1979 · 72 citations
  3. 3Comparison of lidoflazine and quindine in prophylactic treatment of arrhythmias.1977 · 43 citations
  4. 4Prenylamine-induced ventricular tachycardia and syncope controlled by ventricular pacing.1980 · 29 citations
  5. 5THE EFFECTS OF GANGLION‐BLOCKING AND POSTGANGLIONIC SYMPATHOLYTIC DRUGS ON PREPARATIONS OF THE GUINEA‐PIG VAS DEFERENS1963 · 68 citations