November 1, 1998Journal of VirologyOpen Access

Intracellular Localization of Poliovirus Plus- and Minus-Strand RNA Visualized by Strand-Specific Fluorescent In Situ Hybridization

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Population

HEp-2 cells infected with poliovirus

Design

Preclinical

Authors

Discussion

Reveals poliovirus RNA strand dynamics in infected cells; leaves open mechanistic roles and antiviral targets for future study.

Population

HEp-2 cells infected with poliovirus

Intervention

Fluorescent in situ hybridization (FISH) with strand-specific riboprobes and immunofluorescence (IF)

Outcome

Intracellular localization of poliovirus plus- and minus-strand RNA

The study visualizes the distinct intracellular localization and migration of poliovirus plus- and minus-strand RNA during the replication cycle.

Bolten et al. (1998) studied this question.

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