Population
Poliovirus-infected HEp-2 cells
Design
Preclinical
Authors
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Membrane dependence of poliovirus initiation may inform targeted antivirals; leaves open translation beyond animal cell models.
In poliovirus replication, the initiation of plus-strand RNA synthesis, but not its elongation, is dependent on vesicular membranes.
Egger et al. (1996) studied this question.
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