October 1, 1980Clinical and Experimental Pharmacology and Physiology

Reduced Responses to Noradrenaline of Isolated Digital Arteries From Hypertensives

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Population

Strips of digital arteries obtained post-mortem from 13 hypertensives and 13 normotensives (n=26)

Comparison

In vitro exposure to noradrenaline, serotonin… vs Strips of digital arteries from normotensives

Design

Preclinical

Authors

RMRobert F.W. MouldsTherapeutic Guidelines

Discussion

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Implication

Cautions against extrapolating animal vessel reactivity to human hypertension care; leaves open receptor changes as research targets.

Structured PICO

Population

Strips of digital arteries obtained post-mortem from 13 hypertensives and 13 normotensives (n=26)

Intervention

In vitro exposure to noradrenaline, serotonin, angiotensin, barium chloride, and 80 mmol/l KCl

Comparator

Strips of digital arteries from normotensives

Outcome

Maximum responses and pED50 values to vasoactive substances (noradrenaline, serotonin, angiotensin, barium chloride, KCl)surrogate

Hypertensive vascular smooth muscle exhibits reduced maximum responses to noradrenaline and serotonin, suggesting a decreased number of alpha-receptors.

Cite This Study

Robert F.W. Moulds (1980) studied this question.

synapsesocial.com/papers/6a8565dd916c5a6accada10e https://doi.org/10.1111/j.1440-1681.1980.tb00100.x

Topics

Hypertension management

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Reduced Responses to Noradrenaline of Isolated Digital Arteries From Hypertensives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Reduced Responses to Noradrenaline of Isolated Digital Arteries From Hypertensives

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider