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May 1, 1975Experimental Biology and Medicine

K+ and Mg2+ Net Fluxes in Relation to Zero Ca2+ Perfusion and Subsequent Cardiac Contracture

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Population

Rabbit heart model

Comparison

Zero [Ca2+] perfusion for 12 minutes followed by… vs Shorter periods of Ca2+-lack arrest followed by…

Design

Preclinical

Authors

NPNorman F. ParadiseUniversity of AkronMVMaurice B. VisscherUniversity of Southern California

Discussion

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Implication

May caution against zero-calcium perfusates in research models; leaves open clinical relevance of calcium paradox to reperfusion injury.

Structured PICO

P
Population
Rabbit heart model
I
Intervention
Zero [Ca2+] perfusion for 12 minutes followed by restoration of normal ionic composition perfusion
C
Comparator
Shorter periods of Ca2+-lack arrest followed by restoration of [Ca2+]
O
Outcome
K+ and Mg2+ net fluxes and cardiac contracturesurrogate

Prolonged zero calcium perfusion in rabbit hearts increases membrane permeability, causing massive calcium influx and contracture upon reperfusion, followed by explosive potassium and magnesium efflux.

Cite This Study

Paradise et al. (1975) studied this question.

synapsesocial.com/papers/6a858f805fbeaf52a2ae6281https://doi.org/10.3181/00379727-149-38739
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Magnesium net fluxes and distribution in rabbit myocardium in irreversible contracture1978 · 11 citations
  2. 2ON THE ROLES OF CALCIUM ION DURING POTASSIUM INDUCED CONTRACTURE IN THE SMOOTH MUSCLE CELLS OF THE RABBIT MAIN PULMONARY ARTERY1977 · 31 citations
  3. 3Calcium movements during potassium contracture in isolated rabbit aortic strips1962 · 76 citations
  4. 4Role of cation gradients in hypercontracture of myocytes during simulated ischemia and reperfusion1993 · 31 citations
  5. 5Mechanism of ischemic contracture in ferret hearts: relative roles of [Ca2+]i elevation and ATP depletion1990 · 111 citations