Poliovirus-cell complexes stabilize against 32P decay during the first 3 hours of infection, likely due to early RNA production.
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May reflect early RNA synthesis stabilizing poliovirus complexes; leaves open mechanistic validation in modern models.
Suicide experiments with 32 P-labeled poliovirus were performed with HeLa S 3 cells. The results show that virus–cell complexes become increasingly refractory to 32 P decay during the eclipse period, i.e., stabilization to 32 P decay occurs during the first 3 h of infection. The data suggest that stabilization is probably due in part to the production of early RNA during the eclipse period because the presence of 32 P in the medium during the first 2 h of growth sensitizes infective centers.
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Hughes et al. (1971) studied this question.
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