Key result
Among patients with coronary artery disease, circulating angiogenin levels were inversely correlated with ejection fraction (r = -0.17, P = 0.02) and positively related to wall motion scores.
Why the study?
Are circulating biomarkers of angiogenesis associated with left ventricular systolic dysfunction in patients with coronary artery disease?
Population
194 patients with coronary artery disease (aged 34-81 years) undergoing elective coronary angiography
Design
Cross-sectional
Authors
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Angiogenin modestly associated with worse LV function in CAD; hypothesis-generating and requires prospective validation before any clinical role.
Cross-Sectional (n=194)
Are circulating biomarkers of angiogenesis associated with left ventricular systolic dysfunction in patients with coronary artery disease?
Effect estimate: r = -0.17
p-value: p=0.02
Circulating biomarkers of angiogenesis, particularly angiogenin, show modest correlations with left ventricular systolic dysfunction in patients with coronary artery disease.
Patel et al. (2009) conducted a cross-sectional in Coronary artery disease (n=194). Circulating biomarkers of angiogenesis (angiogenin, VEGF, Ang-1, Ang-2) was evaluated on Correlation of angiogenin levels with ejection fraction (r = -0.17, p=0.02). Among patients with coronary artery disease, circulating angiogenin levels were inversely correlated with ejection fraction (r = -0.17, P = 0.02) and positively related to wall motion scores.
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