Why the study?
Does interatrial shunting improve right heart dynamics and systemic perfusion in a canine model of chronic pulmonary hypertension?
Population
8 dogs with chronic pulmonary hypertension (CPH) induced by 3 months of progressive pulmonary artery banding
Comparison
8-mm shunt prosthesis inserted between the… vs Preshunt baseline ('CPH')
Design
Preclinical
Authors
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Low-flow interatrial shunting merits optimization in experimental PH; leaves open human translation and ideal flow rates.
Does interatrial shunting improve right heart dynamics and systemic perfusion in a canine model of chronic pulmonary hypertension?
In a canine model of chronic pulmonary hypertension, low-flow interatrial shunting improved right atrial mechanics and systemic perfusion, while high-flow shunting reduced systemic oxygen delivery.
Zierer et al. (2009) studied this question.
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