Why the study?
Does the Björk-Shiley mechanical valve cause more mechanical trauma to red blood cells compared to the Carpentier-Edwards biologic valve in patients with normally functioning valve prostheses?
Does the Björk-Shiley mechanical valve cause more mechanical trauma to red blood cells compared to the Carpentier-Edwards biologic valve in patients with normally functioning valve prostheses?
The Björk-Shiley mechanical valve causes greater mechanical trauma and reduction in red cell deformability compared to the Carpentier-Edwards biologic valve.
BS valve linked to greater RBC trauma than CE; Level 3 data leaves open relevance for hemolysis or valve selection.
The haemolytic properties of mechanical and biologic valve prostheses are well established, and it is known that they can shorten red cell survival time (1, 2). Their effects on red cell deformability are not known, however. A comparative study was therefore made of two valve types--Björk-Shiley (BS) and Carpentier-Edwards (CE). Thirty-nine patients with normally functioning valve prostheses (23 BS, 16 CE) were studied at least one year after surgery, by assessing red cell deformability measured as red cell filtration rate (RFR), red cell survival half-time with the Cr-51 isotope method (Cr-51 T1/2) and plasma-haemoglobin (P-Hb). The BS valve was shown to be more traumatic to the cells than the CE valve and effected greater reduction of the deformability of these cells. Significant intercorrelations were found between RFR, CR-51 T1/2 and P-Hb.
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Hirayama et al. (1985) studied this question.
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