Why the study?
Do poliovirus vaccines reduce the incidence of paralytic poliomyelitis in the general population?
Do poliovirus vaccines reduce the incidence of paralytic poliomyelitis in the general population?
Both Salk and Sabin poliovirus vaccines are clinically safe and effective, with the Salk vaccine reducing paralytic poliomyelitis incidence by approximately 90%.
Supports historical Salk vaccine efficacy; leaves open need for updated trials in current populations.
PoliomyelitisThe safety and effectiveness of both the killed (Salk) and the live oral (Sabin) poliovirus vaccines have now been established clinically. Statewide programs are going forward to immunize large segments of the population against poliomyelitis with the latter. Such mass campaigns are useful in initiating population-wide immunity,11 but the new crop of infants who enter the susceptible phase will probably require individual immunization for protection.EffectivenessSalk poliovaccine has been extremely effective in reducing, by approximately 90 per cent, the incidence of paralytic poliomyelitis. Nonetheless, paralytic poliomyelitis has continued to occur in both immunized and unimmunized persons. In a . . .
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Taub et al. (1963) studied this question.
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