Key result
An integrated RF/OCT ablation catheter accurately monitored lesion formation (93% accuracy) and predicted pop events (86% accuracy) in in-vitro poultry and ovine heart models.
Why the study?
Current catheter ablation procedures are limited in safety and efficacy by the inability to accurately monitor lesion formation.
Does an integrated RF/OCT ablation catheter accurately monitor lesion formation and tissue characteristics in in-vitro heart models?
Does an integrated RF/OCT ablation catheter accurately monitor lesion formation and tissue characteristics in in-vitro heart models?
A novel integrated RF/OCT ablation catheter demonstrates high accuracy for real-time monitoring of lesion formation and tissue characterization in in-vitro models, potentially improving ablation safety and efficacy.
May advance lesion monitoring in ablation; leaves open clinical translation from preclinical data.
The inability of current catheter ablation procedures to accurately monitor lesion formation limits their safety and efficacy. An advanced fully integrated radiofrequency (RF)/optical coherence tomography (OCT) ablation catheter is developed, which enables real-time monitoring during ablation. An OCT fiber array is especially designed, developed and integrated into an off-the-shelf irrigated RF ablation catheter. In-vitro experimental studies performed on poultry and ovine hearts demonstrate the ability of the integrated RF/OCT system to provide information on the quality and orientation of catheter/wall contact. Experimental results show that adipose tissue can be accurately identified from normal myocardial tissue with 94% accuracy and lesion formation is monitored with an overall accuracy of 93%. The ability to predict pop events is also demonstrated, with an accuracy of 86%.
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Tiporlini et al. (2020) studied Atrial fibrillation. Integrated radiofrequency/optical coherence tomography (RF/OCT) ablation catheter was evaluated on Accuracy of monitoring lesion formation. An integrated RF/OCT ablation catheter accurately monitored lesion formation (93% accuracy) and predicted pop events (86% accuracy) in in-vitro poultry and ovine heart models.
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